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Customs and Incidents: Borgia
It is recorded of the infamous Pope Alexander VI. (Borgia) that he caused a key, similar to the key-ring, to be used in opening a cabinet, but the Pope's key was poisoned in the handle, and provided with a small sharp pin, which gave a slight puncture, sufficient to allow the poison to pass below the skin. When he wished to rid himself of an objectionable friend he would request him to unlock the cabinet; as the lock turned rather stiffly, a little pressure was necessary on the key handle, sufficient to produce the effect desired.